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Jester69420
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Recommended Posts

1. Killing Patrick McReary at the beginning of the game via random event (lose him as a heist member)

2. Returning players content random events

3. Simeon Yetarian random event

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^ In addition to what has been mentioned above:

4. Altruist camp shootout (deliver four victims to the Altruist Cult camp as Trevor to trigger it, but there are characters from random events you might not want to sacrifice, like unlockable heist members).
5. Exploiting the stock market in conjunction to assassination missions given to Franklin by Lester in order to be able to afford all businesses. Look at the sticked thread in this section.
6. Pick a right ending option if you don't want to lose one of the protagonists and his exclusive safehouse(s), garages, vehicles and side content.

However, no matter what choices you make during the playthrough, you still can't be locked out of 100% completion.

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