Morons03 Posted June 3, 2015 Share Posted June 3, 2015 Saw this on RT.com a few days ago and thought of posting, but never got to signing in. I never saw it on Yahoo news or the news app on Win8, so I thought this would be a nice place to post it. First successful study of virus attack on cancer Date: May 28, 2015 Source: University of Louisville Summary: It's a new weapon in the arsenal of cancer fighting treatments: utilizing genetically modified viruses to invade cancer cells and destroy them from the inside. Now scientists have found that stage IIIb to IV melanoma patients treated with a modified cold sore (herpes) virus had improved survival. University of Louisville researcher Jason Chesney, M.D., Ph.D., deputy director of the James Graham Brown Cancer Center (JGBCC), and a team of international scientists found that stage IIIb to IV melanoma patients treated with a modified cold sore (herpes) virus had improved survival. The results of the findings were published recently in the Journal of Clinical Oncology. UofL was one of the major sites for the phase III clinical trial involving 436 patients who received the viral immunotherapy, talimogene laherparepvec (T-VEC). Scientists genetically engineered the herpes simplex I virus to be non-pathogenic, cancer-killing and immune-stimulating. The modified herpes virus does not harm healthy cells, but replicates when injected into lesions or tumors, and then stimulates the body's immune system to fight the cancer. "The results from this study are amazing," Chesney said. "Patients given T-VEC at an early stage survived about 20 months longer than patients given a different type of treatment. For some, the therapy has lengthened their survival by years. " Shari Wells from Ashland, Kentucky is one of those patients. She entered the trial in 2010 with stage IV, or metastatic, melanoma. Before entering the T-VEC trial, she had been through numerous procedures and major surgeries. According to Wells, nothing worked and she was facing a death sentence. "When you hear that you may only have three to six months to live, it is very scary," Wells said. "I would not be alive today if I had not been accepted into the T-VEC trial. Dr. Chesney and the James Graham Brown Cancer Center saved my life." Wells drove to Louisville every two weeks for about two and a half years to receive injections in each of the more than 60 lesions on her leg. The lesions eventually began to fade and finally disappeared. She has been in remission for almost three years. "I want everyone to know they should never give up hope. With research there will always be something new tomorrow that wasn't here today," she said. The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are considering findings from the trial to make the treatments available to more patients with advanced melanoma. More Research The Journal of Clinical Oncology report comes on the heels of Chesney's findings from another study published this month in the New England Journal of Medicine. The article describes an immunotherapy for melanoma utilizing the checkpoint inhibitors, ipilimumab and nivolumab. In cell biology, their role is to reduce the effectiveness of two immune checkpoint proteins responsible for telling the immune system to turn off and not kill the cancer cells. The study found that injection of the two inhibitors shrunk tumors in the majority of patients with advanced melanoma. The JGBCC was one of the top centers worldwide to enroll patients and find that ipilimumab combined with nivolumab resulted in the highest anti-cancer efficacy ever observed after treatment with a cancer immunotherapy. Chesney and his team, working with the pharmaceutical company Amgen, are taking the success of their trials a step further -- combining T-VEC with the immune checkpoint inhibitor ipilimumab into a treatment regimen. The clinical trial is underway at the JGBCC and other sites in hopes of accelerating cancer immunity and curing patients. "We finally understand how to activate the human immune system to clear cancer cells, having developed new classes of immunotherapies that dramatically improve the survival of cancer patients," Chesney said. "I believe T-VEC combined with immune checkpoint inhibitors will not only reduce cancer-related mortality in melanoma but in all cancer types, and we are moving quickly to develop these methods." Story Source: The above story is based on materials provided by University of Louisville. Note: Materials may be edited for content and length. Journal Reference: R. H. I. Andtbacka, H. L. Kaufman, F. Collichio, T. Amatruda, N. Senzer, J. Chesney, K. A. Delman, L. E. Spitler, I. Puzanov, S. S. Agarwala, M. Milhem, L. Cranmer, B. Curti, K. Lewis, M. Ross, T. Guthrie, G. P. Linette, G. A. Daniels, K. Harrington, M. R. Middleton, W. H. Miller, J. S. Zager, Y. Ye, B. Yao, A. Li, S. Doleman, A. VanderWalde, J. Gansert, R. Coffin. Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma. Journal of Clinical Oncology, 2015; DOI: 10.1200/JCO.2014.58.3377 MLA Citation: University of Louisville. "First successful study of virus attack on cancer." ScienceDaily. ScienceDaily, 28 May 2015. <www.sciencedaily.com/releases/2015/05/150528163139.htm>. TL;DR: It's a new weapon in the arsenal of cancer fighting treatments: utilizing genetically modified viruses to invade cancer cells and destroy them from the inside. Now scientists have found that stage IIIb to IV melanoma patients treated with a modified cold sore (herpes) virus had improved survival. Sauce: http://www.sciencedaily.com/releases/2015/05/150528163139.htm# xVampire Fangx 1 Link to comment Share on other sites More sharing options...
Jack Marston Posted June 3, 2015 Share Posted June 3, 2015 Looks like GTAForums will finally be cured. Dottie, universetwisters, Testarossa and 3 others 6 Link to comment Share on other sites More sharing options...
El Dildo Posted June 3, 2015 Share Posted June 3, 2015 fortunately, this sh/t is no joke. science is finally beginning to understand the particular biology of cancer cells and we've begun using viruses (instead of antibiotics or radiation) to kill them. and it's working. Dingdongs, Raavi, Abel. and 1 other 4 Link to comment Share on other sites More sharing options...
Mr. Scratch Posted June 3, 2015 Share Posted June 3, 2015 Is this really it? Did they finally figure it out? Link to comment Share on other sites More sharing options...
dudclub55 Posted June 3, 2015 Share Posted June 3, 2015 Is this really it? Did they finally figure it out? Only time will tell. Cancer is an incredibly complex and difficult to cure myriad of diseases. Clem Fandango 1 Link to comment Share on other sites More sharing options...
bread Posted June 3, 2015 Share Posted June 3, 2015 Looks like GTAForums will finally be cured. Nice join date Link to comment Share on other sites More sharing options...
Coin Posted June 3, 2015 Share Posted June 3, 2015 Is this really it? Did they finally figure it out? I don't think this is it, but it is definitely a step in the right direction. Very, very promising though. Link to comment Share on other sites More sharing options...
Jack Marston Posted June 3, 2015 Share Posted June 3, 2015 Looks like GTAForums will finally be cured. Nice join date Thank you. I think July 27th, 2011 is a very attractive looking date next to your profile. Affalterbach 1 Link to comment Share on other sites More sharing options...
Mr. Scratch Posted June 3, 2015 Share Posted June 3, 2015 Either that or we'll turn into those albino mutants from I Am Legend. Taylor 1 Link to comment Share on other sites More sharing options...
Smith John Posted June 3, 2015 Share Posted June 3, 2015 Or those albino mutants. Mr. Scratch 1 bash the fash m8s Link to comment Share on other sites More sharing options...
El Dildo Posted June 3, 2015 Share Posted June 3, 2015 Is this really it? Did they finally figure it out? there's no single "cure" yet. but they've begun showing - in actual clinical HUMAN trials, not rats or monkeys - that certain cancer cells can be destroyed by certain viruses. as in eliminated permanently. the virus is genetically modified to ONLY target and kill the cancer cells, not surrounding tissue. the cancer dies, the patient remains healthy. the trials are literally breaking news. this has been going on for the last 4 years and although the sample size is still small, at least 90% of subjects have shown total remission. so far... Link to comment Share on other sites More sharing options...
Jack Marston Posted June 3, 2015 Share Posted June 3, 2015 I vaguely remember hearing stories about using the polio virus to attack the cancer cell. Or maybe it's something like the polio latches onto the cancer cell, and the body fights the polio, killing the cancer to get to the polio. Link to comment Share on other sites More sharing options...
Mr. Scratch Posted June 3, 2015 Share Posted June 3, 2015 I vaguely remember hearing stories about using the polio virus to attack the cancer cell. Or maybe it's something like the polio latches onto the cancer cell, and the body fights the polio, killing the cancer to get to the polio. Viruses can be repurposed as containers of sorts. El Dildo 1 Link to comment Share on other sites More sharing options...
El Dildo Posted June 3, 2015 Share Posted June 3, 2015 (edited) exactly. the virus is only a delivery system. there's nothing inherently 'bad' about a virus. it depends on how you program it. obviously in nature most viruses are programmed to attack the host. so they seem bad. but we now have the technology and knowledge to reprogram them. Edited June 3, 2015 by El Diablo Link to comment Share on other sites More sharing options...
Mr. Scratch Posted June 3, 2015 Share Posted June 3, 2015 It's somewhat similar to how vaccines are made, you either use a part of the virus, as in hepatitis B or HPV vaccines or by using a part of a bacteria, you inactivate the toxin in it with formalin or heat treatment and it becomes a toxoid. Another strategy to make a bacterial vaccine is to use part of the sugar coating of the bacteria. Protection against infection by certain bacteria is based on immunity to this sugar coating (and not the whole bacteria). Usually kids don't have very good immune response to the sugar coating alone, so the coating is linked to a harmless protein, which basically gives you a conjugated polysaccharide vaccine. El Dildo 1 Link to comment Share on other sites More sharing options...
MyName'sJeff Posted June 4, 2015 Share Posted June 4, 2015 (edited) Yes but it's nothing to be excited over just yet, though it's a step in the right direction. As far as they are concerned, they've warned us that there are possible severe side effects. Once they try and stablise the cure or whatever, without any issues occuring at all, they'll probably go full steam ahead with the testing and officially announce something. Edited June 4, 2015 by MyName'sJeff Link to comment Share on other sites More sharing options...
Mr. Scratch Posted June 4, 2015 Share Posted June 4, 2015 They did officially announce something. This is something. El Dildo and Niko Montana 2 Link to comment Share on other sites More sharing options...
Affalterbach Posted June 4, 2015 Share Posted June 4, 2015 As long as the f*cking illuminati exist there wont come a cure for cancer. Tbh i actually do believe that there is a cure for cancer, but its in the hands of the f*cking illuminati. Link to comment Share on other sites More sharing options...
El Dildo Posted June 4, 2015 Share Posted June 4, 2015 As long as the f*cking illuminati exist good news: they don't. mr quick, Fonz, Coin and 2 others 5 Link to comment Share on other sites More sharing options...
mr quick Posted June 4, 2015 Share Posted June 4, 2015 (edited) As long as the f*cking illuminati exist good news: they don't. lucky larry silverstein!!! wake up america Also, I'd argue that if anything intentionally stagnates a "cure", it'd be capitalism. That's a whole different debate, though. Edited June 4, 2015 by Marwin Fonz 1 Link to comment Share on other sites More sharing options...
reiniat Posted June 4, 2015 Share Posted June 4, 2015 but they've begun showing - in actual clinical HUMAN trials, not rats or monkeys - that certain cancer cells can be destroyed by certain viruses. as in eliminated permanently. the virus is genetically modified to ONLY target and kill the cancer cells, not surrounding tissue. the cancer dies, the patient remains healthy. the trials are literally breaking news. this has been going on for the last 4 years and although the sample size is still small, at least 90% of subjects have shown total remission. so far... Isnt that exactly the plot of I Am Legend? Payne Killer, Finn 7 five 11 and Clem Fandango 3 Link to comment Share on other sites More sharing options...
Affalterbach Posted June 5, 2015 Share Posted June 5, 2015 As long as the f*cking illuminati exist good news: they don't.They do. Just look that sh*t up man. Clem Fandango 1 Link to comment Share on other sites More sharing options...
El Dildo Posted June 5, 2015 Share Posted June 5, 2015 they don't. your conspiracy theory is confusing a cancer 'vaccine' for a cancer 'cure.' huge difference Clem Fandango 1 Link to comment Share on other sites More sharing options...
Coin Posted June 5, 2015 Share Posted June 5, 2015 Just what this thread needed; illuminati mentions. Not. Link to comment Share on other sites More sharing options...
Dingdongs Posted June 5, 2015 Share Posted June 5, 2015 (edited) Is this really it? Did they finally figure it out? there's no single "cure" yet. but they've begun showing - in actual clinical HUMAN trials, not rats or monkeys - that certain cancer cells can be destroyed by certain viruses. as in eliminated permanently. the virus is genetically modified to ONLY target and kill the cancer cells, not surrounding tissue. the cancer dies, the patient remains healthy. the trials are literally breaking news. this has been going on for the last 4 years and although the sample size is still small, at least 90% of subjects have shown total remission. so far... I saw a thing on 60 minutes where they had been using measles to kill cancer, which is interesting. I don't know much of anything about biology... is each type of cancer caused by different cells? So one virus would only kill say, a particular kind of lung cancer? Edited June 5, 2015 by Irviding Link to comment Share on other sites More sharing options...
Morons03 Posted June 5, 2015 Author Share Posted June 5, 2015 It seems like that is how its working. More research and testing might find more something to use on most types. Link to comment Share on other sites More sharing options...
El Dildo Posted June 6, 2015 Share Posted June 6, 2015 I saw a thing on 60 minutes where they had been using measles to kill cancer, which is interesting. I don't know much of anything about biology... is each type of cancer caused by different cells? So one virus would only kill say, a particular kind of lung cancer? that's it, more or less. instead of having a virus deliver some kind of horrific germ into your bloodstream, we can program the virus to deliver specific antibodies that are programmed only to attack the type of cancer we desire. Dingdongs 1 Link to comment Share on other sites More sharing options...
gtamann123 Posted June 6, 2015 Share Posted June 6, 2015 The world is overpopulated as it is. Link to comment Share on other sites More sharing options...
sivispacem Posted June 6, 2015 Share Posted June 6, 2015 The world is overpopulated as it is.No, it really isn't. Raavi, Clem Fandango, Coin and 2 others 5 AMD Ryzen 5900X (4.65GHz All-Core PBO2) | Gigabye X570S Pro | 32GB G-Skill Trident Z RGB 3600MHz CL16 EK-Quantum Reflection D5 | XSPC D5 PWM | TechN/Heatkiller Blocks | HardwareLabs GTS & GTX 360 Radiators Corsair AX750 | Lian Li PC-O11 Dynamic XL | EVGA GeForce RTX2080 XC @2055MHz | Sabrant Rocket Plus 1TB Sabrant Rocket 2TB | Samsung 970 Evo 1TB | 2x ASUS ROG Swift PG279Q | Q Acoustics 2010i | Sabaj A4 Link to comment Share on other sites More sharing options...
gtamann123 Posted June 6, 2015 Share Posted June 6, 2015 The world is overpopulated as it is. No, it really isn't.Tell that to me again on Monday morning when I'm sitting in traffic at 8 AM. There way too many peeps Link to comment Share on other sites More sharing options...
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