Definitely nowhere in East or South Los Santos; Inglewood, Jefferson, Playa de Seville, Willowfield or Corona.
In SF, Doherty.
In LV, Whitewood, Creek, or Red Sands. The hell with anywhere in Bone County. Snake farms, body pits, military base, airliner graveyard, ghost towns, deserted Indian pueblos, huge radiotelescope, a UFO themed bar, brothels, dams in the middle of the desert, oil rigs. Oh yeah, a giant rooster and a f***ton of hot dry sand. The whole place is like the set of "The Hills Have Eyes" or the Trinity test site. Its so bad that you actually feel like you've reached civilization if you make to Fort Carson where Marvin Trill is yakking on air about aliens and Kifflom next to a trailer park. The women might be worth flirting with if they would stop talking about their trailer and the last cousin they scored with.
if I'm slumming, I might use that one safe-house in west Jefferson if I feel like hanging around the skate park or looking for trouble in Ganton/Inglewood
I did make a little crummy flat across the street from my LA office to duck in from time to time. I like it for a modest place to take a quiet break or stay if I'm downtown "over night". Its nice to go small sometimes. I like to celebrate my trashiness sometimes.