Oh wow. You do have a weird glitch in your save. I used SnP's modification tool to convert the save to v1 scripts so I could test things in my controlled environment. Don't worry about the conversion process, I'm a wiz at this sort of thing. I was able to reproduce the glitch, sort of. It's not a consistent crash. Once it crashed right out the door. Next time I had to drive down the road and back before it crashed. Then I cleared the global and weather timers, which disables all of the scripts, and it crashed just down the road from the safe house.
The crash with scripts disabled is good news. That eliminates a lot of possibilities. There's a reasonably good chance I can fix this glitch. The next step in the process is to copy and paste good blocks from my saves over the blocks in your save until the problem goes away. Once the glitched save structure is isolated I can start forming a hypothesis on what the problem might be. Right now I'm clueless. I've been tracking save glitches for years and haven't seen anything like this. I figure any glitch I haven't seen by now is probably caused by mods, but I'd be very much surprised if ENB did this sort of thing.
But I'm too tired right now, and too busy this week. It's liable to be a long time before I can take another look. You might consider starting a new game in the meantime. Have you ever made a starter save? 4 star exploration is lots of fun. You could also start a save for collecting special vehicles. There's a lot of collectors around here since we've got an awesome guide linked in the strategies forum.
Blocks replaced without resolution:
- Garage block 3
- Pickups block 6
- Markers block 9
- Zones block 10
- Car Generators block 12
- Unique Stunt Jumps block 24
- Enex block 25