I liked this game, but what kind of got me about the story was the heavy involvement of the McReary family. You do missions for Packie, Gerry, Derrick and even Francis. It was almost like how at some point, the game placed a lot of focus on them. Sure, we had Niko dealing with different types and they all were connected to various contacts, like Playboy X being an associate of Elizabeta, the Pegorino crime family working with the McRearys, etc. Sure, Packie stays around as a friend and the closing bit with the storyline was Gerry telling you that he is in jail for life. Also, depending on who you kill between Derrick or Francis, you don't see either anymore, though you can call Francis to bail you out of a jam in regards to wanted level. Derrick, on the other hand, just disappears.
One other thing, depending if Kate dies in the end, did anybody notice that Packie said that he was the only one his mom has left? I know the fate between Francis and Derrick was determinant, and I know it was only a piece of dialogue that Packie said that she had "that smack-head Derrick," but even if you did spare him, I wonder what could have happened. I know in V, Packie said that he died (Depending on whether you killed him or maybe he OD'ed), but I can only guess he died by the end of IV if that were the case.
I didn't mind that bit of storyline with that family, but it seemed like there was a lot of focus on them at some point.