If you play from a disc then it more than likely your bluray laser lens. Depending on the model (original, 120 slim, 160 slim, super slim) you'll need to find a tut on how to clean it. The Super Slim is extremely easy to clean and the 160GB model is the easiest of the one that have to be opened.
I highly doubt that's the case since all my games work fine with no freeze at all but since the new patch, GTA V always freezes after a couple of minutes when playing. I have the 120 slim btw
Thats how it starts, with a single game. When my Bluray lens was dirty at first it only affected BF3, then RDR and then GTA IV and then every other game. You really should look into before it gets worse. In my case the laser lens on my 160GB died completely because i took to long address the issue. Went and got a Super Slim afterwards, much easier to clean.
I should note that after i got my new system i have only frozen once and that was due to a connection issue.