- Streetlights and even some trees move in the wind during a thunderstorm.
- Niko has dialogue for each street in Liberty City when directing a cab driver, unlike in GTA V where the protagonists only name in which district they want to go.
- Michelle doesn't drink on dates, and judging by Niko's comments spikes his drinks to get information out of him.
- In First Date, Niko mentions how some of Michelle's furniture still has tags on it. This is foreshadowing her betrayal, and showing that it's just a temporary government apartment.
- The United Liberty Paper Company is a front for the IAA, as revealed in GTA V.
- Alex's blog indicates that Niko has a large...appendage.
- Certain peds can survive incredible damage. Once, I shot a Jamaican twice in the chest with a shotgun, point blank, and he was still alive on the ground.
- In Bleed Out, Niko has different responses depending on how you deal with Dardan. If you knock him out, Niko will say "That's what we owe you, Dardan. Nothing else". If you kill him by Sparta kicking him out the window, Niko will throw his arms up and say "I promised myself I wouldn't kill people here!". If you disarm him and stab him with his own knife, Niko will laugh and say "You shouldn't play with sharp objects, Dardan." If you get lucky and manage to perform a drive-by on Dardan before he runs up the stairs, Roman will say "Wow! Thank you cousin. Where did you get a gun?".
- The injury system was awesome.
Seriously, it was. I just encountered this today; I was playing Bleed Out again, and was at the point where I had to confront Dardan. I ran up unarmed against his knife, but got lucky and punched him square in the face. He went down immediately despite having full health, and I grabbed his knife and walked away with Niko satisfied with not killing him. As I stepped onto the outdoor catwalk of the factory with a view of the Humboldt River, I stopped for a second to look at the sunset and Dardan came limping from nowhere, walking by me. As he did, he said "You broke my arm already, man!" and faltered away. There was a small gap in the metal fence that looked to the Humboldt, and of all places he went right into that gap. He fell, screaming. I ran up to the gap in time to see him slam onto the edge of the concrete, then spiral into the river, dead.