I played V while on about 3 hits of acid about a year ago. I was on the mission where you race the 2 guys on the highway then arrest them to steal there cars.
The whole time, the road was warping into a point on the center of the screen and would unwarp as I drove through it. And later I stopped playing entirely because of some graffiti near Franklin's house, it was basically stair welling downward, it went from from green to purple to orange and back to green as it would "step down". It's tough to put to words. Long story short it's fun but there's no way in hell I could actually get through a game tripping like that.