I see a lot of people bring it up, so I know I'm not the only one who's disappointed in the lack of choices when it comes to safehouse locations. I was personally letdown from the start to find that you could only purchase them in the city.
I know it's probably just a pipe dream, but when I was flying around looking for a place to make another deathmatch I noticed the apartment complex across from the Blaine County Bank in Paleto Bay definitely looked suitable as a safehouse, and it got me thinking. Sandy Shores and Grapeseed are mostly made up of standalone buildings, so it'd be hard to make them work out unless they built something new in unless you want to live in the sh*tty rundown motels in Sandy Shores or Harmony.
Out of all the places Paleto Bay is the most likely. It's the largest and most developed of the three, and isn't a rundown sh*thole. Something else to note is the South Seas apartment complex, Mojito Inn, and Dr (insertletterhere)am View Motel all have for rent signs on them, so maybe there's actually something to look forward to there. The town also has all the commodities you'd expect a place you'd be living in to have, so who knows, maybe some of us may be living there some day.
I know it's expecting a lot right now and if it does happen it won't be for a long time, but this is just a fantasy poll more than anything.