He starts doing meth and moves to Liberty City.
5 years later...
We see our new protag, Trisha, having sex with Franklin's girlfriend, Tanisha, also a meth head (I know she was getting married, don't ask). All of a sudden, Trisha sees on the TV that his long time disappeared friend, Michelle, was alive. He proceeds to go out.
There we see Franklin walking towards Trisha's apt., angry because he was f*cking his girl. Lamar and Stretch follow him while they say "Don't do it, Frank, it ain't worth it" (Ending A/B ends up being canon, so the story takes place after Frank kills one of his friends, therefore, Stretch is alive and ends up being friends with F).
Trisha walks out, holding a cup of whisky with his right hand. He ignores all the sh*t Franklin tells to him as he walks down the street.
"Hey, Trisha! I'm talking to you, dogf*cker" (Trisha was drunk one night and he accidently raped Chop. Everyone made fun of him, so he gets angry everytime someone reminds him that he is a dogf*cker), says Franklin.
Trisha truns around. "Oh... are you? So... what are you sayin'?"
"Banging my girl, dawg. It ain't cool."
"So... do you want me to bang you instead? C'mere, Mr. Gangbanger, take off your pants"
"Knock it off, nigga-"
"-TAKE THEM OFF".
"Hey, man, I'm leavin' before you take advant-" says Franklin, while Trisha interrupts him and throws him to the ground, smashes his cup on his face and then proceeds to stomp on his skull, killing him.
Then Trisha kills both Stretch and Lamar. He gets in his car and drives to Families territory (because after the events of V they moved to LC because you touch yourself at night).