I'm going to take a lot of sh*t for this one but...
Yes. It has. I tried to play V for the first time in a couple of months yesterday, I was honestly so bored I turned it off after 20 minutes. That said, I tried playing IV and EFLC as well, and they also bored the sh*t out of me. Maybe it was just the mood I was in.
Skyrim, though - I've been playing it constantly for 3 years and it just doesn't get old. What's that all about? What has it got that GTA hasn't?
I'll answer your question: Big + Beauty + RPG, few words to the wise is sufficient.