Lol wicked topic idea.
I do read the manual just for the sake of seeing little previews of what's coming up, usually in the car on the way back.
I will switch it on and leave the controller until I have to use it, I always do that with GTA games, watch all the intro and get ready.
If the 1st mission is not required to free roam a bit I think that's what I'll do, for SA I didn't want to get used to the world quick so I only did the missions without exploring, I wish I would have just free roamed to the limits because it's part of the game you can only experience by doing, and that I will with GTA 4.
Whileroaming I'll 'walk about and do as I please, beat a few old ladies up, see a nice car I'm taking it (and that'll probably be the first car I see period because GTA 4 will look stunning in any motor), run over a few peds whilst enjoying the scenery, maybe even get a Police chase to spice it up and get used to the car control, apart from that I really can't say exacly what I'll do. But rolling as joint first is a must.
You creating this talk about what we will do is making me want the game even more, now that I'm thinking of opening the case and playing it, you bastard!
Only jokin' mate, welcome to the forums.